Mysterious Linkages Between Hepatitis C Virus Genotypes, Interleukin-28B Genotypes and Viral Clearance- A Meta-Analysis

Mysterious Linkages Between Hepatitis C Virus Genotypes, Interleukin-28B Genotypes and Viral Clearance- A Meta-Analysis

BACKGROUND Recent genome wide association studies (GWAS) have shown important roles of single nucleotide polymorphisms (SNP) near region of interleukin B 28 (IL28B) gene in spontaneous and drug-induced clearance of hepatitis C virus (HCV) in genotype 1 HCV infection. OBJECTIVES This meta-analysis was designed to determine the world-wide distribution patterns of IL28B genotypes and alleles, an...

mysterious linkages between hepatitis c virus genotypes, interleukin-28b genotypes and viral clearance- a meta-analysis

conclusions there were significant linkages between hcv genotypes and il28b genotypes/alleles. patients with a favorable il28b and genotypes 1 and 4 hcv infection stand a better chance to clear hcv in the acute phase. objectives this meta-analysis was designed to determine the world-wide distribution patterns of il28b genotypes and alleles, and to find possible linkages between il28b and hcv ge...

Corrigendum to: Mysterious Linkages Between Hepatitis C Virus Genotypes, Interleukin-28B Genotypes and Viral Clearance-A Meta-Analysis [Published in Hepatitis Monthly. 2014 Mar; 14(3): e15895]

This corrigendum/addendum supplies corrected Table 1 which had missed rows for SNPs and genotypes/alleles.American Ethnicity a rs12979860 rs8099917 rs12979860 rs8099917 CC CT TT GG GT TT C T G T Caucasian HCV Genotype 1a Data are presented as mean (95%CI), %.

corrigendum to: mysterious linkages between hepatitis c virus genotypes, interleukin-28b genotypes and viral clearance-a meta-analysis [published in hepatitis monthly. 2014 mar; 14(3): e15895]

Hepatitis C Virus: Viral Quasispecies and Genotypes

Hepatitis C virus (HCV) mainly replicates in the cytoplasm, where it easily establishes persistent infection, resulting in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Due to its high rate of mutation, HCV forms viral quasispecies, categorized based on the highly variable regions in the envelope protein and nonstructural 5A protein. HCV possesses seven major genotypes, amon...